Review What’s New for Tier 2 MoPath Codes in July 2017

july 2017

All of you who have never read the descriptor for a tier 2 molecular pathology procedure code, go check out 81400-81408. Then tip your hat to MoPath coders because those code descriptors are lo-o-o-o-ng.

To add to the fun, CPT® releases descriptor changes for these codes more than once a year. The descriptor changes effective July 1, 2017, take four pages to list, so in this post we’ll look only at additions. You can find the complete list under Downloads on AMA’s CPT® Molecular Pathology Tier 2 Codes site.

These changes were posted to the AMA site Jan. 1, 2017; are effective July 1, 2017; and will be published in the CPT® 2018 manual.

Look for New Tests Listed Under 81405

Before starting its long list of tests, the descriptor for 81405 begins with “Molecular pathology procedure, Level 6 (e.g., analysis of 6-10 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 11-25 exons, regionally targeted cytogenomic array analysis).”

(Would be nice if 81405 was for level 5 and not level 6, right? But you can’t have everything.)

Effective July 1, insert these additions to the descriptor for 81405:

  • CPOX (coproporphyrinogen oxidase) (e.g., hereditary coproporphyria), full gene sequence
  • CTRC (chymotrypsin C) (e.g., hereditary pancreatitis), full gene sequence
  • PKLR (pyruvate kinase, liver and RBC) (e.g., pyruvate kinase deficiency), full gene sequence.

Code 81406 Adds 2, Too

The descriptor for level 7 code 81406 begins this way: “Molecular pathology procedure, Level 7 (e.g., analysis of 11-25 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 26-50 exons, cytogenomic array analysis for neoplasia).”

  • HMBS (hydroxymethylbilane synthase) (e.g., acute intermittent porphyria), full gene sequence
  • PPOX (protoporphyrinogen oxidase) (e.g., variegate porphyria), full gene sequence.

How About You?

Do you report MoPath tests? What tips would you offer someone just starting out in the specialty?


Deborah works on a wide range of TCI SuperCoder projects, researching and writing about coding, as well as assisting with data updates and tool development for our online coding solutions. Since joining TCI in 2004, she’s covered the ins and outs of coding for radiology, cardiology, oncology and hematology, orthopedics, audiology, and more.

, , , ,

Leave a Reply